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目的:分析帕金森病患者外周神经病变程度及维生素B12水平,探讨神经病变及体位平衡的相关性。方法:随机选取50例帕金森病患者及50例年龄性别相当的健康对照者使用肌电图进行神经功能评估,检测血清叶酸及维生素B12水平,并通过临床Tinetti量表评估平衡功能。结果:帕金森病患者外周神经功能较对照组明显下降,叶酸及维生素B12水平低于对照组,维生素B12浓度与帕金森病患者周围神经损害程度呈负相关,帕金森病患者临床平衡能力与外周神经传导速度呈正相关。结论:帕金森病患者周围神经功能损伤较健康同龄人显著增多,其原因主要为帕金森病患者体内叶酸、维生素B12的缺乏。而外周神经功能病变可导致帕金森病患者体位平衡能力的进一步下降。
OBJECTIVE: To analyze the degree of peripheral neuropathy and the level of vitamin B12 in patients with Parkinson’s disease and to explore the correlation between neuropathy and body position balance. METHODS: Fifty Parkinson’s disease patients and 50 age-matched healthy controls were randomly selected to perform neurological evaluation using electromyography. Serum folic acid and vitamin B12 levels were measured and the balance function was assessed using the clinical Tinetti scale. Results: The peripheral nerve function of patients with Parkinson’s disease was significantly lower than that of the control group. The levels of folic acid and vitamin B12 were lower than those of the control group. The concentration of vitamin B12 was negatively correlated with the degree of peripheral nerve damage in patients with Parkinson’s disease. Nerve conduction velocity was positively correlated. CONCLUSIONS: Parkinson’s disease peripheral neurological impairment significantly increased compared with healthy peers, mainly due to folic acid and vitamin B12 deficiency in patients with Parkinson’s disease. Peripheral neuropathy can lead to further decline in posture balance in patients with Parkinson’s disease.