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目的：探讨雷公藤碱戊的免疫药理作用。方法：采用系统性红斑狼疮（ＳＬＥ）病人外周血单个核细胞（ＰＢＭＣ）体外培养观察雷公藤碱戊对ＳＬＥ病人ＰＢＭＣ的Ｂ细胞功能的影响及时效关系。结果：雷公藤碱戊能抑制ＳＬＥ的ＰＢＭＣ自发性增殖反应以及正常人和ＳＬＥ病人ＰＢＭＣ对ＳＡＣ刺激后的增殖反应。同时在培养的７２ｈ前加入雷公藤碱戊均能对正常人ＰＢＭＣ在ＰＷＭ诱导下的ＩｇＧ产生呈现抑制效应。结论：雷公藤碱戊对Ｂ细胞功能的多个环节具有抑制作用，其抑制Ｂ细胞产生ＩｇＧ的作用环节可能在于抑制了Ｂ细胞的活化增殖阶段
Objective: To investigate the immunopharmacological effects of tripterygium wilfordii. Methods: Peripheral blood mononuclear cells (PBMCs) from patients with systemic lupus erythematosus (SLE) were cultured in vitro to observe the effects of triptolide on the B cell function of PBMCs in SLE patients and the time-effect relationship. RESULTS: Tripterygium wilhiensis inhibited the spontaneous proliferative responses of SLE PBMCs and PBMCs stimulated by SAC in normal and SLE patients. At the same time, the addition of tripterygium pentobarbital 72h before culture could inhibit the production of IgG induced by PWM under normal conditions. CONCLUSION: Tripterygium wil has inhibitory effect on many aspects of B cell function, and the inhibitory effect of B cells on the production of IgG may rest on the stage of activation and proliferation of B cells