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目的探讨奥曲肽在非手术治疗恶性肠梗阻中的有效性和安全性。方法回顾性分析我院1996年5月~2010年1月因肿瘤导致恶性肠梗阻行非手术治疗的患者共44例,常规治疗组19例,给予禁食、止酸、胃肠减压、纠正水电解质和酸碱平衡紊乱、营养支持以及应用抗生素等对症支持治疗;奥曲肽治疗组25例,在常规治疗基础上加用奥曲肽0.1mg,ih,q8h,治疗周期为6 d。比较两组患者临床症状改善情况、胃肠减压量变化情况。结果奥曲肽组腹部症状缓解的总有效率高于常规治疗组(P<0.05),在症状缓解时间、胃肠减压引流量方面,奥曲肽组优于常规治疗组,差异有统计学意义(P<0.05)。整个治疗过程未见与奥曲肽相关的明显不良反应。结论常规方法联合奥曲肽治疗恶性肠梗阻安全、有效,可缓解患者的临床症状,值得临床推广。
Objective To investigate the efficacy and safety of octreotide in the treatment of malignant intestinal obstruction. Methods A retrospective analysis of our hospital from May 1996 to January 2010 due to malignant intestinal obstruction due to tumor in patients with non-surgical treatment of a total of 44 cases, 19 cases of conventional treatment group, given fasting, acid, gastrointestinal decompression, correction Water and electrolyte and acid-base balance disorders, nutritional support and the use of antibiotics and other symptomatic and supportive treatment; octreotide treatment group 25 cases, based on conventional therapy plus octreotide 0.1mg, ih, q8h, the treatment cycle was 6 d. The improvement of clinical symptoms and the changes of gastrointestinal decompression were compared between the two groups. Results The total effective rate of octreotide in relieving abdominal symptoms was higher than that of the conventional treatment group (P <0.05). The octreotide group was superior to the conventional treatment group in symptom relief time and gastrointestinal decompression and drainage volume (P < 0.05). No significant adverse events associated with octreotide were observed throughout the course of treatment. Conclusion The conventional method combined with octreotide in the treatment of malignant intestinal obstruction is safe and effective, which can relieve the clinical symptoms of patients and deserve clinical promotion.