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目的 检测c-junmRNA在胃癌组织中的表达,探讨c-junmRNA在胃癌发展中的作用。方法 利用核酸原位杂交技术对于36例胃癌组织及11例正常胃黏膜组织进行检测。结果 c-junmRNA在正常胃黏膜组织无阳性表达,而c-junmRNA在胃癌组织表达的阳性率为52. 78% ( 19 /36 ),且二者差异有显著性,但与性别、年龄、浸润深度及淋巴结有无转移无关(P<0. 05)。结论 c-junmRNA在胃癌组织有较高的表达,检测c-junmRNA可作为诊断胃癌的分子标志。
Objective To detect the expression of c-jun mRNA in gastric cancer and to explore the role of c-jun mRNA in the development of gastric cancer. Methods In situ hybridization was used to detect 36 cases of gastric carcinoma and 11 cases of normal gastric mucosa. Results The positive expression rate of c-jun mRNA in gastric mucosa was 52.78% (19/36), and there was a significant difference between them Depth and lymph node metastasis (P <0.05). Conclusions c-jun mRNA is highly expressed in gastric cancer tissues. Detection of c-jun mRNA can be used as a molecular marker in the diagnosis of gastric cancer.