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目的:探讨进展期胃癌温热灌注化疗的疗效。方法:对38例胃癌CT分期在T3期以上合并腹水患者,术中行腹腔镜探查,发现腹膜转移或腹水中病理证实癌细胞阳性者,实施腹腔热灌注化疗,术后短期内评价效果,评价腹水改善情况及腹腔脱落肿瘤细胞的阳性率。结果:全组38例患者,完全缓解20例,部分缓解12例,有效率84%,15例发生恶心、呕吐,11例白细胞下降,未发现穿孔、出血、梗阻及感染等。结论:针对进展期胃癌合并腹腔积液,并经术中腹水病理检测脱落癌细胞阳性患者,实施腹腔热灌注化疗可以较大限度杀灭腹腔肿瘤细胞,提高进展期胃癌生活质量,经转化治疗后有望重新获得手术机会。
Objective: To investigate the curative effect of hyperthermic perfusion chemotherapy for advanced gastric cancer. Methods: Thirty-eight patients with ascites diagnosed by CT staging of T3 or more were retrospectively analyzed. Laparoscopy was used to detect peritoneal metastasis or pathologically confirmed cancer cells in peritoneal cavity. Intraperitoneal hyperthermic perfusion chemotherapy was performed. Short-term postoperative evaluation of ascites Improve the situation and the rate of tumor cells in peritoneal exfoliation. Results: The complete group of 38 patients, complete remission in 20 cases, partial remission in 12 cases, the effective rate was 84%, nausea and vomiting in 15 cases, 11 cases of leukopenia, no puncture, bleeding, obstruction and infection were found. CONCLUSION: For patients with advanced gastric cancer complicated with ascites, and ascites detected by intraoperative ascites pathology, intraperitoneal hyperthermic perfusion chemotherapy can kill the peritoneal tumor cells to a large extent and improve the quality of life of advanced gastric cancer. After the treatment of conversion Is expected to regain the chance of surgery.