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目的探讨尼莫地平对脑出血后继发性脑损害的保护作用机理。方法60例脑出血患者随机分为尼莫地平组与常规治疗组,所有患者均分别在治疗前后观察脑水肿、临床神经功能缺损评分、Barthel指数评分、临床疗效及日常生活依赖程度的变化。结果尼莫地平组和常规治疗组治疗后水肿带均明显缩小,尼莫地平组缩小更为明显(P<0.01);治疗后尼莫地平组临床神经功能缺损评分较常规治疗组明显降低(P<0.01);治疗后尼莫地平组较常规治疗组BI评分明显增加,日常生活活动依赖程度明显减低(P<0.01);治疗后尼莫地平组临床疗效总有效率(73%)显著高于常规治疗组(40%)(P<0.05);治疗后尼莫地平组较常规治疗组日常生活活动依赖程度明显减低(P<0.05)。结论尼莫地平治疗脑出血有确切疗效,可减轻脑水肿,保护神经细胞,可减轻患者神经功能缺损程度,提高患者生活质量。
Objective To investigate the protective effect of nimodipine on secondary brain injury after intracerebral hemorrhage. Methods 60 patients with cerebral hemorrhage were randomly divided into nimodipine group and conventional treatment group. All patients were observed before and after treatment of brain edema, clinical neurological deficit score, Barthel index score, clinical efficacy and daily living dependence changes. Results The nimodipine group and conventional treatment group were significantly reduced edema zone after treatment, nimodipine group decreased more significantly (P <0.01); after treatment nimodipine group clinical neurological deficit score was significantly lower than the conventional treatment group (P (P <0.01). After treatment, the BI score of nimodipine group was significantly higher than that of routine treatment group (P <0.01), and the total effective rate (73%) of nimodipine group was significantly higher than that of routine treatment group The routine treatment group (40%) (P <0.05). After treatment, the nimodipine group was significantly less dependent on daily activities than the conventional treatment group (P <0.05). Conclusion Nimodipine is effective in treating cerebral hemorrhage, which can reduce brain edema and protect nerve cells, reduce the degree of neurological deficits and improve the quality of life of patients.