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目的通过观察盐酸米诺环素(MHO)辅助一站式全口龈下刮治和根面平整术(FM-SRP治疗)和分象限全口龈下刮治和根面平整术(Q-SRP)治疗中重度慢性牙周炎效果,探讨局部应用药物辅助治疗的必要性和最佳治疗方案的选择。方法将80例中重度慢性牙周炎患者随机分为4组:FM-SRP-MHO组和Q-SRP-MHO组SRP同时均辅助使用盐酸米诺环素;FM-SRP组和Q-SRP组仅SRP,不辅助用药。分别在基线、3个月和6个月时,检测菌斑指数(PI)、牙龈指数(GI)、探诊出血(BOP)、探诊深度(PD)及附着丧失(AL)的变化及患者的术后反应。所得结果分别进行秩和检验(PI,GI)、t检验(PD、AL)和χ2检验(BOP)。结果 4组患者治疗前后PD、BOP、AL各值相比有统计学意义(P<0.01);其中FM-SRP-MHO组和Q-SRP-MHO组分别与FM-SRP和Q-SRP相比PD、BOP、AL各值相比有统计学意义(P<0.01)。结论治疗中重度慢性牙周炎临床效果FM-SRP-MHO法优于FM-SRP,Q-SRP-MHO法优于QSRP法,表明SRP的同时局部辅以盐酸米诺环素是慢性牙周炎较好的治疗方法。
Objective To observe the effects of minocycline hydrochloride (MHO) one-stop total mouth subgingival scaling and root-surface plaster (FM-SRP) and sub-quadrant subgingival scaling and root- ) Treatment of moderate to severe chronic periodontitis effect, to explore the need for local application of drug adjuvant therapy and the best treatment options. Methods Eighty patients with moderate-to-severe chronic periodontitis were randomly divided into 4 groups: FM-SRP-MHO group and Q-SRP-MHO group assisted with both minocycline and FM-SRP group and Q-SRP group Only SRP, not supporting medication. The changes of plaque index (PI), gingival index (GI), probing bleeding (BOP), probing depth (PD) and attachment loss (AL) were measured at baseline, 3 months and 6 months, Postoperative response. The results obtained by rank sum test (PI, GI), t test (PD, AL) and χ2 test (BOP). Results Compared with FM-SRP and Q-SRP, FM-SRP-MHO group and Q-SRP-MHO group had statistically significant differences before and after treatment (P <0.01) PD, BOP, AL values were statistically significant (P <0.01). Conclusion The clinical effect of FM-SRP-MHO is better than that of FM-SRP in the treatment of moderate-chronic chronic periodontitis. Q-SRP-MHO is superior to QSRP, indicating that SRP is supplemented with minocycline hydrochloride for chronic periodontitis Better treatment.