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原发性骨质疏松症分为绝经后骨质疏松症和老年性骨质疏松症两种类型,其发病率在50岁以上女性中为60%左右,而在老年男性中发病率约达30%,骨折既是骨质疏松最常见也是最严重的并发症,部位多发于脊柱、髋部和腕部的尺桡骨,本病及其相关并发症严重影响患者的生命质量甚至导致死亡。西药治疗主要是针对骨质疏松本身及其骨折引起的疼痛,相关报道主要涉及抑制破骨细胞活性、促进成骨细胞生成和促进骨化等药物,现简要综述如下。
Primary osteoporosis is divided into two types of postmenopausal osteoporosis and senile osteoporosis, the incidence rate of about 60% of women over the age of 50, while in older men, the incidence rate of about 30 %. Fractures are both the most common and the most serious complication of osteoporosis. The multiple sites occur in the ulna and radius of the spine, hip and wrist. The disease and its complications seriously affect the quality of life of patients and even cause death. Western medicine treatment is mainly targeted at the pain caused by osteoporosis itself and its fractures, the related reports mainly involve inhibiting osteoclast activity, promoting osteoblast generation and promoting ossification and other drugs, are briefly summarized as follows.