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目的 探讨康莱特注射液对胃肠道恶性肿瘤患者免疫功能的影响。方法 对 ５０ 例胃肠道恶性肿瘤病人分别于术前、术后３ 周抽取外周血对 Ｔ 淋巴细胞亚群和血清 Ｓ Ｉ Ｌ２ Ｒ 水平表达进行检测，随机将 ５０ 例患者分为单纯手术组（２８ 例）和应用康莱特组（２２ 组），并与 ４２ 例健康人对照比较。结果 与正常对照组相比胃肠道恶性肿瘤病人 Ｔ 淋巴细胞亚群中 Ｃ Ｄ３＋ 细胞、 Ｃ Ｄ４＋ 细胞减少， Ｃ Ｄ４＋ ／ Ｃ Ｄ８＋ 细胞比值下降（ Ｐ＜ ０．０５），血清 Ｓ Ｉ Ｌ２ Ｒ 水平升高（ Ｐ＜ ０．０１）；手术切除肿瘤后， Ｃ Ｄ３＋ 细胞、 Ｃ Ｄ４＋ 细胞增加， Ｃ Ｄ４＋ ／ Ｃ Ｄ８＋ 细胞比值升高（ Ｐ＜ ０．０５），血清 Ｓ Ｉ Ｌ２ Ｒ 水平降低（ Ｐ＜ ０．０１）。使用康莱特注射液后， Ｃ Ｄ３＋ 细胞、 Ｃ Ｄ４＋ 细胞明显增加， Ｃ Ｄ４＋ ／ Ｃ Ｄ８＋ 细胞比值增高（ Ｐ＜ ０．０５）， Ｓ Ｉ Ｌ２ Ｒ水平下降（ Ｐ＜ ０．０５）。结论 康莱特注射液能明显提高胃肠道恶性肿瘤患者的免疫功能。
Objective To investigate the effect of Kanglaite injection on immune function of patients with gastrointestinal cancer. Methods 50 patients with gastrointestinal malignancies were enrolled in the preoperative and postoperative 3 weeks to detect T lymphocyte subsets and serum S II L 2 R expression. Randomly divide 50 patients into surgery. The group (28 cases) and the Kanglaite group (22 groups) were compared with 42 healthy subjects. Results Compared with the normal control group, C D3+ cells and C D4+ cells in the T lymphocyte subsets of patients with gastrointestinal cancer were decreased, the ratio of C D4+ / C D8+ cells was decreased (P<0.05), serum S I L 2 R levels increased (P<0.01); after surgical removal of tumors, C D3+ cells, C D4+ cells increased, C D4+/C D8+ cell ratios increased (P< 0.05), serum S I L 2 R Levels decreased (P < 0.01). After KLT injection, C D3+ cells and C D4+ cells increased significantly, the ratio of C D4+ / C D8+ cells increased (P<0.05), and the level of S II L 2 R decreased (P< 0.05). Conclusion Kanglaite injection can significantly improve the immune function of patients with gastrointestinal cancer.