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目的了解某综合医院耐甲氧西林金黄色葡萄球菌(MRSA)医院感染控制效果。方法对2005年1月1日-2010年12月31日所有MRSA培养阳性的住院患者进行调查;2008年7月1日-2010年12月31日采取前瞻性调查方法对MRSA感染及定植患者采取综合控制措施;2005年1月1日-2008年6月30日采取回顾性调查,分析综合控制措施的效果。结果通过采取综合控制措施,MRSA医院发病的感染(MRSA-HOI)率明显下降,从1.22例次/万住院日降至0.64例次/万住院日(P=0.00),不同感染部位中呼吸系统和泌尿系统干预后MRSA-HOI感染率明显下降(P<0.05);而不同部门中,ICU MRSA-HOI所占比例最高(40.40%)并取得较为显著的控制效果。结论采取预防控制措施可有效防止MRSA在医院内的传播。
Objective To understand the control effect of methicillin-resistant Staphylococcus aureus (MRSA) hospital infection in a general hospital. Methods All hospitalized patients with positive MRSA culture were investigated from January 1, 2005 to December 31, 2010; patients with MRSA infection and colonization were enrolled in the prospective investigation from July 1, 2008 to December 31, 2010 Comprehensive control measures; January 1, 2005 - June 30, 2008 to take a retrospective survey to analyze the effect of integrated control measures. Results The rates of MRSA-MRI hospital infection (MRSA-HOI) decreased significantly from 1.22 cases per 10,000 hospital days to 0.64 cases per 10,000 hospital days (P = 0.00) through comprehensive control measures. The respiratory system (P0.05) .In the different departments, the proportion of MRSA-HOI in ICU was the highest (40.40%) and the more significant control effect was obtained. Conclusion Prevention and control measures can effectively prevent the spread of MRSA in the hospital.