β-地中海贫血是广东广西常见的遗传性疾病,临床上根据贫血的严重程度分为轻型、中间型及重型地贫[1]。中重型β-地中海贫血中有纯合子和双重杂合子,由于类型组合的不同,临床表现轻重不一,实验结果各异。笔者应用反向点杂交技术共检测出22例中重型β地中海贫血,并对他们进行血 β-thalassemia is a common genetic disease in Guangxi province of Guangdong. According to the severity of anemia, it is classified into mild, intermediate and severe thalassemia [1]. There are homozygotes and double heterozygotes in middle-heavy β-thalassemia. Due to the different types of combinations, the clinical manifestations vary in severity and the experimental results are different. Twenty-two cases of β-thalassemia major and β-thalassemia were detected by reverse dot blot technique, and their blood