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53例老年人与18例青年人的清晨血浆或唾液皮质醇浓度,以及青、老龄鼠的血浆皮质酮浓度之间均未见明显差异。但在采用 Cortrosyn 负荷试验时,老年人的唾液皮质醇或老龄鼠肾上腺皮质细胞体外培养的皮质酮增长值均明显低于青年人及青龄鼠,说明老年人或鼠肾上腺皮质储备功能都有减退。老年人及老龄鼠经温肾益气药治疗后,其Cortrosyn 试验增长值较对照组均有明显提高,说明补肾药具有明显改善肾上腺皮质老年性变化的作用。
There was no significant difference in the morning plasma or saliva cortisol concentrations between 53 elderly patients and 18 young adults, and plasma corticosterone concentrations in young and old rats. However, when using the Cortrosyn stress test, the growth of corticosterone in aged saliva cortisol or old rat adrenocortical cells cultured in vitro was significantly lower than that in young and young rats, indicating that the elderly or rats have reduced adrenal cortical reserve function. . After elderly and aged rats were treated with Wenshenyiqi medicine, their Cortrosyn test growth values were significantly higher than those in the control group, indicating that kidney tonic drugs can significantly improve the adrenal cortical effects of aging.