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目的 :比较黄山药总苷 (DX)和薯蓣皂苷元 (Dio)抗实验性高脂血症及体外抗血小板聚集作用强度。方法 :给小鼠和大鼠喂饲高胆固醇饲料造成高脂血症模型 ,之后灌胃或腹腔注射给予DX和Dio ,测定血清胆固醇含量。结果 :给小鼠灌胃DX( 4 0 0和 2 0 0mg·kg-1)和Dio( 160和 80mg·kg-1)时 ,Dio对小鼠高胆固醇血症有明显预防和治疗作用 ,而DX只有大剂量时才有一定预防作用。腹腔注射给药时 ,Dio( 4 0和 2 0mg·kg-1)仍然有效 ,但DX无效。给大鼠灌胃DX( 4 0 0和 2 0 0mg·kg-1)和Dio( 2 0 0和 10 0mg·kg-1) ,均能明显降低血中总胆固醇含量 ,但在上述剂量 ,Dio的预防效果明显优于DX。DX( 60～ 2 4 0 μg·ml-1)和Dio( 3 0～ 12 0 μg·ml-1)体外有明显的抗血小板聚集活性 ,但Dio的抑制率明显高于DX。结论 :Dio抗高脂血症及抗血小板聚集作用明显优于DX。
Objective : To compare the anti-hyperlipidemia and in vitro anti-platelet aggregation effects of total glucosides (DX) and diosgenin (Dio). METHODS: Hypercholesterolemia model was induced by feeding high cholesterol diets to mice and rats. DX and Dio were administered by gavage or intraperitoneal injection to measure serum cholesterol levels. RESULTS: When mice were given DX (400 and 2000 mg·kg-1) and Dio (160 and 80 mg·kg-1) by gavage, Dio had significant preventive and therapeutic effects on hypercholesterolemia in mice. DX only has a preventive effect when in large doses. Dio (40 and 20 mg·kg-1) remained effective at the time of intraperitoneal injection, but DX was not effective. Rats given intragastric administration of DX (400 and 200 mg·kg-1) and Dio (200 and 100 mg·kg-1) significantly reduced blood total cholesterol, but at the above dose, Dio The preventive effect is significantly better than DX. DX (60-240 μg·ml-1) and Dio (30-120 μg·ml-1) had significant antiplatelet aggregation activity in vitro, but the inhibition rate of Dio was significantly higher than that of DX. Conclusion : Dio is superior to DX in antihyperlipidemia and antiplatelet aggregation.