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间尼索地平和尼索地平１ｍｇ／ｋｇ和３ｍｇ／ｋｇ单次灌胃或反下注射，均可显著降低自发性高血压大鼠的血压，在用药后最初几小时可见心率加快．两药降压程度相似．且作用持久，均可维持２４小时。每天灌胃１次，连续给药１４天，在用药期间，间尼索地平和尼索地平１ｍｇ／ｋｇ和３ｍｇ／ｋｇ，使大鼠血压一直维持在较低水平，但停药后血压恢复较快，间尼索地平维持降压作用时间略长于尼索地平，长期给药对心率影响不明显．
Nisoldipine and nisoldipine 1mg / kg and 3mg / kg single gavage or anti-retrograde injection, can significantly reduce spontaneous hypertension in rats, the first few hours after treatment can be seen in the heart rate. Two antihypertensive levels are similar. And lasting effect, can be maintained for 24 hours. Gavage once daily for continuous administration for 14 days, during the medication, nisoldipine and nisoldipine 1mg / kg and 3mg / kg, the blood pressure in rats has been maintained at a low level, but after stopping the recovery of blood pressure than Fast, nisoldipine to maintain a slightly longer duration of antihypertensive effect than nisoldipine, long-term administration of the heart rate was not obvious.