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目的研究中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)与老年ST段抬高型心肌梗死(STEMI)及PCI术后短期主要不良心血管事件(MACE)的关系。方法选取接受PCI治疗的老年STEMI患者116例及健康体检者116例,分析NLR、PLR及其他主要临床生化指标与老年STEMI的关系,评估术前、术后NLR及PLR的变化对PCI术后MACE发生的预测价值。结果老年STEMI患者组高血压患病率、UA、LDL-C水平、WBC、NLR、PLR均明显高于对照组;而RBC、Hb则明显低于对照组,差异有统计学意义(P<0.05)。老年STEMI患者无MACE组NLR及PLR数值术后均较术前明显下降,差异有统计学意义(P<0.05),而老年STEMI患者合并MACE组NLR及PLR数值术前、术后无明显变化。结论 NLR及PLR是老年STEMI的独立危险因素,且与PCI术后的短期预后有关。
Objective To investigate the relationship between neutrophil and lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), STEMI in elderly patients and major adverse cardiovascular events (MACE) after PCI. Methods One hundred and sixty-six elderly STEMI patients and 116 healthy subjects undergoing PCI were enrolled in this study. The relationship between NLR, PLR and other major clinical and biochemical indexes and elderly STEMI was analyzed to evaluate the changes of preoperative and postoperative NLR and PLR. The predicted value of occurrence. Results The prevalence of hypertension, UA, LDL-C, WBC, NLR and PLR in elderly patients with STEMI were significantly higher than those in the control group, while those in RBC and Hb were significantly lower than those in the control group (P <0.05 ). There was no significant difference in NLR and PLR between elderly STEMI patients and those without MACE postoperatively (P <0.05). However, there was no significant change in NLR and PLR before and after treatment in elderly STEMI patients with MACE. Conclusion NLR and PLR are independent risk factors for senile STEMI and are related to short-term prognosis after PCI.