This work investigates one immune optimization algorithm in uncertain environments, solving linear or nonlinear joint chance-constrained programming with a general distribution of the random vector. In this algorithm, an a priori lower bound estimate is developed to deal with one joint chance constraint, while the scheme of adaptive sampling is designed to make empirically better antibodies in the current population acquire larger sample sizes in terms of our sample-allocation rule. Relying upon several simplified immune metaphors in the immune system, we design two immune operators of dynamic proliferation and adaptive mutation. The first picks up those diverse antibodies to achieve proliferation according to a dynamical suppression radius index, which can ensure empirically potential antibodies more clones, and reduce noisy influence to the optimized quality, and the second is a module of genetic diversity, which exploits those valuable regions and finds those diverse and excellent antibodies. Theoretically, the proposed approach is demonstrated to be convergent. Experimentally, the statistical results show that the approach can obtain satisfactory performances including the optimized quality, noisy suppression and efficiency. This work investigates one immune optimization algorithm in unstable environments, solving linear or nonlinear joint chance-constrained programming with a general distribution of the random vector. In this algorithm, an a priori lower bound estimate is developed to deal with one joint chance constraint, while the scheme of adaptive sampling is designed to make empirically better antibodies in the current population acquire larger sample sizes in terms of our sample-allocation rule. Relying upon several simplified immune metaphors in the immune system, we design two immune operators of dynamic proliferation and adaptive mutation. The first picks up those diverse antibodies to achieve proliferation according to a dynamical suppression radius index, and which reduce empire potential antibodies more clones, and reduce noisy influence to the optimized quality, and the second is a module of genetic diversity, which exploits those valuable regions and finds some diverse and excellent a Experimentally, the statistical results show that the approach can obtain satisfactory performances including the optimized quality, noisy suppression and efficiency.