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目的探讨胃舒宁联合奥美拉唑、克拉霉素、左氧氟沙星抗幽门螺杆菌(Hp)治疗的临床疗效。方法 793例Hp患者随机分成治疗组270例(胃舒宁联合奥美拉唑、克拉霉素、左氧氟沙星)、三联组264例(奥美拉唑、克拉霉素、左氧氟沙星)、对照组259例(奥美拉唑、甲硝唑、阿莫西林)。对三组治疗后的临床疗效进行分析。结果治疗组痊愈率87.0%,有效率4.1%,总有效率91.1%,无效率8.9%,消化道副作用11.9%,且症状轻。三联组痊愈率81.4%,有效率3.0%,总有效率84.5%,无效率15.5%,消化道副作用23.1%。对照组痊愈率64.5%,有效率9.3%,总有效率73.7%,无效率26.3%,消化道副作用43.2%。治疗组与三联组的疗效相当,但消化道副作用明显减轻(P<0.05),治疗组与对照组相比具有明显疗效(P<0.05)。结论中西医结合有良好的抗Hp治疗作用且消化道副作用小的优势,值得研究。
Objective To investigate the clinical efficacy of omeprazole combined with omeprazole, clarithromycin and levofloxacin against Helicobacter pylori (Hp). Methods A total of 793 patients with Hp were randomly divided into treatment group (270 cases, Weishuning combined with omeprazole, clarithromycin and levofloxacin), 264 cases (omeprazole, clarithromycin and levofloxacin) Omeprazole, metronidazole, amoxicillin). The clinical efficacy of the three groups after treatment was analyzed. Results In the treatment group, the cure rate was 87.0%, the effective rate was 4.1%, the total effective rate was 91.1%, the inefficiency rate was 8.9%, the gastrointestinal side effect was 11.9%, and the symptoms were mild. Triple group cured rate of 81.4%, the effective rate of 3.0%, the total effective rate of 84.5%, 15.5% inefficiency, gastrointestinal side effects of 23.1%. The cure rate of the control group was 64.5%, the effective rate was 9.3%, the total effective rate was 73.7%, the ineffective rate was 26.3% and the gastrointestinal side effect was 43.2%. The treatment group and the triple group had the same effect, but the gastrointestinal side effects were significantly reduced (P <0.05), and the treatment group compared with the control group had a significant effect (P <0.05). Conclusion Integrative Chinese and Western medicine has a good anti-Hp treatment and gastrointestinal side effects of small advantages, it is worth studying.