论文部分内容阅读
目的：探讨原发性肾病综合征（ＰＮＳ）的病理变化及与临床疗效的关系。方法：对８７例经肾活检的成人ＰＮＳ患者进行临床与病理观察。结果：最常见的病理类型为系膜增生性肾炎，占６９．０％，其次为局灶性节段性肾小球硬化，占９．２％，膜增生性肾炎占５．７％。轻、中度系膜增生性肾炎对激素及免疫抑制剂治疗效果较好，局灶性节段性肾小球硬化及膜增生性肾炎治疗效果差；对治疗前后的尿Ｎ－乙酰－β－氨基葡萄糖苷酶（ＮＡＧ）及视黄醇结合蛋白（ＲＢＰ）测定结果显示大量蛋白尿易造成肾小管损害。结论：临床疗效与病理类型相关，病变累及肾小管及间质者影响预后
Objective: To investigate the pathological changes of primary nephrotic syndrome (PNS) and its relationship with clinical efficacy. Methods: The clinical and pathological findings of 87 adult PNS patients who had undergone renal biopsy were observed. Results: The most common pathological type was mesangial proliferative glomerulonephritis (69.0%), followed by focal segmental glomerulosclerosis (9.2%) and membranoproliferative glomerulonephritis (5.7%). Mild and moderate mesangial proliferative glomerulonephritis and hormones and immunosuppressive agents better treatment of focal segmental glomerulosclerosis and membranoproliferative glomerulonephritis treatment effect is poor; before and after treatment of urine N-acetyl-β- Glucosaminidase (NAG) and retinol binding protein (RBP) determination results show that a large number of proteinuria easily lead to renal tubular damage. Conclusion: The clinical curative effect is related to the type of pathology, and the affected tubules and interstitial lesions affect the prognosis