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回顾性分析40例99次同种异体肾移植患者及28例正常肾组织HLA－DR抗原表达的变化。发现移植肾的HLA－DR抗原不仅表达有所增强，而且表达的范围亦有所变化。移植后HLA－DR抗原表达的形态学改变分三类：（1）弥漫性增加；（2）局灶节段增加；（3）基本正常。其表达有阳性及弱阳性之分，亦受所取组织之影响，在鉴别肾移植排斥时应注意分析。作者认为在排斥反应未逆转时DR抗原持续强阳性表达，急性排斥时其表达亦增强，但在慢性排斥中DR表达的意义尚需进一步观察。
The changes of HLA-DR antigen expression in 40 cases of renal allograft and 28 cases of normal renal tissue were retrospectively analyzed. HLA-DR antigen found in renal transplant recipients not only increased expression, but also the scope of expression also changed. The morphological changes of HLA-DR antigen expression after transplantation were divided into three categories: (1) diffuse increase; (2) focal segmental increase; (3) basically normal. The expression of positive and weak positive points, also affected by the organization taken, in the identification of renal transplant rejection should pay attention to analysis. The authors suggest that the expression of DR antigen continues to be strongly positive when rejection is not reversed and that the expression is enhanced during acute rejection but the significance of DR expression needs further observation in chronic rejection.