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冠心病(coronary heart disease)是冠状动脉粥样硬化性心脏病(coronaryatherosclerotic heart disease)的简称,指由于冠状动脉粥样硬化使管腔狭窄或阻塞导致心肌缺血、缺氧而引起的心脏病,是严重威胁人类健康的疾病。髓过氧化物酶(myeloperoxidase,MPO)是中性粒细胞嗜天青颗粒产生的一种重要的过氧化物酶,主要存在于嗜中性粒细胞和单核细胞中,MPO可以作为炎症介质参与形成冠状动脉粥样硬化的炎症反应,同时其基因多态性与冠心病具有易感性。1 MPO及其基因多态性1.1 MPO结构 MPO是一种属于过氧化物酶超家族亚铁血红素酶,含两条重
Coronary heart disease (coronary heart disease) is short for coronary atherosclerotic heart disease. It refers to the heart disease caused by stenosis or obstruction of the coronary artery due to myocardial ischemia and hypoxia. Is a serious threat to human health disease. Myeloperoxidase (MPO) is an important peroxidase produced by neutrophil azurophilic granules, mainly in neutrophils and monocytes, and MPO can be involved as an inflammatory mediator The formation of coronary atherosclerosis inflammatory response, while its genetic polymorphism and coronary heart disease susceptibility. 1 MPO and its genetic polymorphism 1.1 MPO structure MPO is a peroxidase superfamily heme enzyme containing two heavy