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对19例不明原因不孕和14例已育健康妇女共33个月经周期中血清锌、铜、铁、锰、镍含量进行分析。结果表明：对照组排卵日血清锌、铜明显低于印泡中期和黄体中期，印泡中期铁、镍含量最高，在周期中呈递减趋势（P均＜0．05）；与对照组比较，不孕组除印泡中期镍减低外，各期血清钢及黄体中期锌、镍、铁均显著增高（P＜0．001，P＜0．05，P＜0．01），而各期血清锌／铜、铁／铜比率明显降低（P＜0．05）。研究提示：正常妇女月经周期中微量元素水平具有规律的周期变化，且相互存在恒定的比值，微量元素的代谢紊乱可能是不明原因不孕的重要因素之一。
The contents of serum zinc, copper, iron, manganese and nickel in 33 cases of unexplained infertility and 14 healthy women were analyzed in 33 menstrual cycles. The results showed that the levels of serum zinc and copper in the control group on ovulation day were significantly lower than those in the mid and mid luteal phase. In the infertility group, the levels of zinc, nickel and iron in the serum and luteal phase were significantly higher than those in the mid-stage of imprinting (P <0.001, P <0.05, P <0.01) Zinc / copper, iron / copper ratio was significantly lower (P <0.05). The study suggests that: the normal menstrual cycle menstrual cycle of the regular level of trace elements, and there is a constant ratio of each other, trace element metabolism may be unexplained infertility one of the important factors.