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目的考察咪唑类离子液体([BMIM][Cl])对人参皂苷Rh1(Rh1)的体外经皮促渗作用及促渗机制。方法以小鼠皮和猪皮为皮肤模型,以油酸、薄荷脑、肉豆蔻酸异丙酯和离子液体[BMIM][Cl]为促渗剂,采用摇瓶法测定Rh1在各促渗剂-水溶液中的溶解度;采用Franz扩散池进行体外经皮渗透实验;采用傅里叶转换红外线光谱(FTIR)法测定研究离子液体的经皮促渗机制。结果与其他促渗剂相比,5%的[BMIM][Cl]能够显著增加Rh1在水中的饱和溶解度;同时对Rh1的体外经皮渗透有显著的促进作用。FTIR的研究结果表明,[BMIM][Cl]能够改变小鼠皮肤角质层结构。结论 [BMIM][Cl]作为一种新型的经皮吸收促渗剂,在外用制剂领域有潜在的使用价值。
Objective To investigate the in vitro transdermal enhancement and mechanism of ginsenoside Rh1 ([BM1]) by imidazole ionic liquid ([BMIM] [Cl]). Methods Mouse skin and pig skin were used as skin models. Oleic acid, menthol, isopropyl myristate and ionic liquid [BMIM] [Cl] were used as skin penetration enhancer. - solubility in aqueous solution; in vitro transdermal permeation test using Franz diffusion cell; and the percutaneous dermal penetration mechanism of ionic liquids was investigated by Fourier transform infrared spectroscopy (FTIR). Results Compared with other penetration enhancers, 5% [BMIM] [Cl] significantly increased the saturated solubility of Rh1 in water, and significantly promoted the transdermal penetration of Rh1 in vitro. FTIR results show that [BMIM] [Cl] can change the mouse cuticle structure. Conclusion [BMIM] [Cl], as a new type of percutaneous absorption enhancer, has potential value in the field of topical preparations.