目的 研究国内分离的4株狂犬病街毒的免疫学特性。方法 采用免疫力试验及中和试验进行抗原性及免疫原性检测。结果4株街毒抗原性存在一定差异，应用aG株疫苗免疫小鼠能保护4株街毒的攻击。结论aG疫苗与4株街毒具有良好的交叉免疫性。 Objective To study the immunological characteristics of four domestic rabies street poisonings. Methods Immunogenicity test and neutralization test were used to detect antigenicity and immunogenicity. Results There were some differences in the antigenicity of four street poisoning strains. The vaccination of mice with aG vaccine could protect against four street poisoning attacks. Conclusion The aG vaccine has good cross-immunity with four street drugs.