目的 研究制作实验性肌炎动物模型的方法。方法利用家兔骨骼肌匀浆加佛氏佐剂多次免疫豚鼠制成实验性肌炎模型，观察其在肌酶、肌电图（ＥＭＧ）、病理的改变。并与人类多发性肌炎（ＰＭ）作比较。结果 发现其与人类多发性肌炎（ＰＭ）在肌酶、肌电图（ＥＭＧ）、病理上的改变有相似之处。结论提示其可作为研究人类ＰＭ的一个重要手段，为人类肌炎的发病机理及治疗提供理论依据。 Objective To study the method of making animal model of experimental myositis. Methods The guinea pigs were immunized guinea pigs with rabbit’s skeletal muscle homogenate plus Freund’s adjuvant to make the experimental myositis model. The changes of muscle enzymes, electromyography (EMG) and pathology were observed. And compared with human polymyositis (PM). It was found to be similar to human polymyositis (PM) in muscle enzymes, electromyography (EMG), and pathological changes. Conclusions suggest that it can be used as an important means to study human PM, provide theoretical basis for the pathogenesis and treatment of human myositis.