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目的:研究中药复方癌痛安的镇痛作用。方法:采用小鼠热板法、扭体法和福尔马林致痛模型来评价癌痛安的镇痛作用;采用小鼠跳跃试验观察癌痛安的成瘾性;用最大耐受量测定来评价癌痛安的安全性。结果:癌痛安以8,4,2g.kg-1剂量灌胃给药,均能明显延长小鼠舔后足所需时间,其痛阈提高率分别为71.71%,66.07%,54.36%;能非常显著地减少小鼠扭体反应的次数,扭体抑制率分别为70.34%,65.75%,64.37%;能有效控制福尔马林所致的小鼠足痛反应。小鼠跳跃试验表明该药无成瘾性。小鼠一日内连续口服癌痛安浸膏4次,总给药量111.82g.kg-1(相当于生药量670.92g.kg-1),为临床成人用药量(180g生药/d)的186.37倍,小鼠无一例死亡。结论:癌痛安具有明显的镇痛作用,且安全无成瘾性。
Objective: To study the analgesic effect of traditional Chinese medicine compound. Methods: The analgesic effect of Guantong’an was evaluated by the mouse hot plate method, writhing method and formalin-induced pain model. The mice’s jumping test was used to observe the addictiveness of Guantong’an. The maximum tolerated dose To evaluate the safety of cancer pain safety. Results: Gutongan administered intragastrically with dosages of 8, 4 and 2 g.kg-1 both prolonged the time needed for licking the hind legs and the rates of improvement of pain threshold were 71.71%, 66.07% and 54.36%, respectively. Can significantly reduce the number of writhing reactions in mice, writhing inhibition rates were 70.34%, 65.75%, 64.37%; can effectively control formalin-induced foot pain response. Jumping tests in mice show that the drug is not addictive. The mice were orally administered with Carcinolone Acetonide 4 times a day for a total of 111.82g.kg-1 (equivalent to 670.92g.kg-1 of crude drug), which was 186.37 for clinical adult dosage (180g crude drug / d) Times, none of the mice died. Conclusion: Guntongan has obvious analgesic effect and is safe and non-addictive.