原发性脑出血(PICH)虽只占脑卒中的10%～15%,但其预后却是各型中较差的。有报道PICH 患者30天的死亡率高达34.6%,6月时的神经功能恢复良好比例仅为38.6%。因此,PICH 是社会的一个重要负担,而且目前对之仍缺乏有效的治疗手段,近年对重组人活化凝血因子Ⅶ(rFⅦa)在脑出血中应用的深入研究,给脑出血的早期治疗带来了希望。脑出血早期的血肿扩大神经功能恶化和早期血肿扩大有关颅内血肿的大小对脑出血患者的生存概率及神经功能的恢复起着重要的决定作用,以往认为颅内出血在发病最初数分钟内即可停止,而之后的神经功能恶化则与血肿周围水肿和容积效应有关,但近来病理解剖、影像学、及临床观察发现早期血肿的扩大是神经功能恶化的重要原因,大量的回顾性或前瞻性研究结果均支持之。Brott 报道,约38%的患者在 Although primary cerebral hemorrhage (PICH) accounts for only 10% to 15% of stroke, its prognosis is poor in all types. PICH patients have been reported 30-day mortality rate as high as 34.6%, in June when the neurological function recovered well only 38.6%. Therefore, PICH is an important social burden, and the current lack of effective treatment of it, in recent years, the recombinant human activated factor Ⅶ (rFⅦa) in cerebral hemorrhage in-depth study of the early treatment of cerebral hemorrhage brought hope. Early hematoma enlargement of cerebral hemorrhage Neurological deterioration and early expansion of hematoma The size of intracranial hematoma plays an important role in determining the survival probability and the recovery of neurological function in patients with intracerebral hemorrhage. In the past, intracranial hemorrhage was considered as the first few minutes of onset However, the subsequent deterioration of neurological function was related to the edema and volume effect around the hematoma. However, recent pathological anatomy, imaging, and clinical observation showed that early hematoma enlargement is an important cause of neurological deterioration. A large number of retrospective or prospective studies The results are supported. Brott reports that about 38% of patients are there