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目的 :本文观察了Qi盐对大鼠实验性高血脂、血黏度及人RBC变形能力的作用。方法 :建立大鼠高血脂模型 ,将Qi盐灌胃给予上述大鼠 ,剂量分别为 0 0 5 ,0 1,0 3,1g·kg-1,连续 2 0d后 ,检查大鼠血脂的变化。体外将人RBC与不同浓度Qi盐混合 ,使RBC溶液中含 0 1,0 2 ,0 4 ,0 8,1 6g·L-1Qi盐 ,37℃孵育 1h后 ,用微孔滤膜法测RBC变形能力 ;正常大鼠连续灌胃Qi盐 2 0d ,剂量分别为 0 1,0 3,1g·kg-1,采血测血黏度。结果 :Qi盐降低大鼠血胆固醇和LDL胆固醇 ,而 1g·kg-1Qi盐还增加大鼠血HDL 胆固醇 ;Qi盐能增加人RBC变形能力 ,0 .8g·L-1浓度时作用最强 ,浓度增高或降低 ,对RBC变形能力的影响减弱 ;0 3g·kg-1或 1g·kg-1的Qi盐可提高全血血黏度 ,但提高幅度不及普通盐。结论 :Qi盐能增加RBC变形能力 ,且有一定的降低血脂趋势
Objective: The purpose of this study was to investigate the effects of Qi salt on experimental hyperlipidemia, blood viscosity and human RBC deformability. Methods: The model of hyperlipidemia in rats was established. Qi-salt was intragastrically administered to rats at 0 0, 0, 10, 3 and 1 g · kg-1, respectively. In vitro, human RBCs were mixed with different concentrations of Qi salt to make 0,02,0.4,0.8,1 6g · L-1Qi salts in RBC solution. After incubated at 37 ° C for 1 hour, RBCs Deformation ability; normal rats were infused Qi salt 20d, the dose was 0 1,0 3,1 g · kg-1, blood viscosity was measured. Qi salt decreased blood cholesterol and LDL cholesterol in rats, and 1g · kg-1Qi salt also increased HDL-cholesterol in rats. Qi salt increased the deformability of human RBC, and the strongest effect was found at the concentration of 0.8g · L-1, The effect of increasing or decreasing the concentration of RBC on the deformability of RBC was weakened. Qi salt of 0 3g · kg-1 or 1g · kg-1 could increase the blood viscosity of whole blood, but the increase was less than that of ordinary salt. Conclusion: Qi salt can increase the deformability of RBC, and reduce the tendency of blood lipid