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目的 评估环丝氨酸在耐多药结核病化学治疗中的应用价值,为进一步优化中国耐多药结核病化学治疗方案提供依据.方法 收集2014-2016年杭州市红十字会医院及温州市中心医院共143例耐多药结核病患者的治疗转归等临床资料,所有患者的治疗符合《世界卫生组织耐药结核病治疗指南(2016年更新版)》中含环丝氨酸的标准治疗方案,总结患者治疗结果、痰菌阴转、药物不良反应发生等情况.结果 143例患者经过含环丝氨酸的标准治疗方案后,总体治疗成功率达到69.2％(99/143);81.1％(116/143)的患者在强化期内实现痰菌阴转.13例患者出现环丝氨酸相关的药物不良反应(9.1％,13/143),包括头晕、头痛7例,四肢麻木3例,肢体抽搐2例,情绪低落1例;所有不良反应在药物减量或者加用对症药物后均缓解.结论 含环丝氨酸的标准治疗方案对耐多药结核病患者进行治疗后,患者总体治疗成功率较高,药物耐受性较好,值得在临床上推广应用.“,”Objective To evaluate the application of cycloserine in the treatment of multidrug-resistant tuberculosis (MDR-TB) and to provide a basis for further optimization of the chemotherapy for MDR-TB patients in China.Methods The clinical data,including treatment outcomes,of 143 MDR-TB patients in Hangzhou Red Cross Hospital and Wenzhou Central Hospital from 2014 to 2016 were collected.All patients received cycloserine-containing standard treatment according to the World Health Organization Treatment Guidelines for Drug-resistant Tuberculosis,2016 Update.The data such as treatment outcome,sputum negative conversion rate,and adverse events associated with drug were summarized.Results Among the 143 patients treated with cycloserine-containing regimen,the overall treatment success rate achieved 69.2％ (99/143).81.1％ (116/143) of patients had sputum culture conversion in the intensive phase.A total of 13 cases (9.1％,13/143) reported adverse events that were considered to be related with cycloserine,including 7 cases who complained of dizziness or headache,3 cases of limb numbness,2 cases of limb twitch and 1 case of depression.All adverse events were relieved by dose reduction or symptomatic treatment.Conclusion Cycloserine-containing standard therapy has high overall success rate and well tolerance for MDR-TB patients,which is worth to be applied in clinical.