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肺炎克雷伯菌(Klebsiella pneumoniae)是一类可引起呼吸道、泌尿道、伤口等部位感染的条件致病菌。生物膜形成能力已被证实与肺炎克雷伯菌的致病性和耐药性相关。肺炎克雷伯菌生物膜形成受多种调控因子的调控。深入研究肺炎克雷伯菌生物膜形成因素和调控网络,对寻找有效的预防与治疗手段具有重要意义。本文就肺炎克雷伯菌生物膜形成相关因素及其调控机制的最新研究近展进行了综述。
Klebsiella pneumoniae is a type of opportunistic pathogen that causes infections in the respiratory tract, urinary tract, and wounds. Biofilm formation ability has been shown to correlate with the pathogenicity and drug resistance of Klebsiella pneumoniae. Klebsiella pneumoniae biofilm formation is regulated by a variety of regulatory factors. In-depth study of Klebsiella pneumoniae biofilm formation factors and regulatory networks, to find effective means of prevention and treatment of great significance. This review summarizes recent studies on the related factors and their regulatory mechanisms of Klebsiella pneumoniae biofilm formation.