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周身应用皮质类固醇可致医源性肾上腺皮质功能不足。这类病人如在麻醉和手术等情况下,难能产生机能应急反应。并可产生低血压、心动过速,可导致休克或死亡。当局部给药(如眼、皮肤和上呼吸道粘膜)均可体内吸收。故经常用皮质类固醇眼药可使肾上腺皮质功能受到抑制。本文以及吡啶酮肾上腺皮质抑制试验研究及眼滴用皮质类固醇病人的下丘脑-垂体-肾上腺轴的联合作用。15名病人用0.1％地塞米松磷酸钠点眼,每日四次,每次一滴(1/30cc)共6周。
Whole-body application of corticosteroids can cause iatrogenic adrenal insufficiency. Such patients, such as anesthesia and surgery, difficult to produce a functional emergency response. And can produce hypotension, tachycardia, can lead to shock or death. When administered locally (such as the eye, skin and upper respiratory tract mucosa) can be absorbed in vivo. It is often used corticosteroid ophthalmic adrenal function can be inhibited. This article, as well as pyridone adrenal cortical inhibition test and ocular drops of corticosteroids in patients with hypothalamus - pituitary - adrenal axis joint effect. Fifteen patients were spotted with 0.1% dexamethasone sodium phosphate, four drops daily (1/30 cc) for 6 weeks.