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目的:观察普萘洛尔、硝苯地平、卡托普利对清醒的二肾一夹(2KIC)高血压大鼠压力感受反射敏感性(BRS)的影响。方法:用改良的Smyth方法测BRS。结果:2KIC高血压大鼠的BRS显著降低,服用普萘洛尔和卡托普利能改善BRS,而硝苯地平没有这一作用。结论:这对预测抗高血压药能否改善高血压的预后有临床意义。
Objective: To observe the effects of propranolol, nifedipine and captopril on baroreflex sensitivity (BRS) in sober 2KIC hypertensive rats. Methods: A modified Smyth method was used to measure BRS. RESULTS: BRS was significantly reduced in 2KIC hypertensive rats, propranolol and captopril improved BRS, whereas nifedipine did not. Conclusion: This is of clinical significance in predicting whether antihypertensive drugs can improve the prognosis of hypertension.