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目的：研究丙氨酰谷氨酰胺在消化道肿瘤术后辅助化疗致腹泻的预防及治疗效果。方法：将术后接受辅助化疗的40例恶性消化道肿瘤患者随机分为两组，对照组化疗20例，观察组为丙氨酰谷氨酰胺+化疗20例，观察两组的腹泻情况。结果：观察组腹泻发生率为15%，对照组40%，观察组与对照组比较，腹泻发生率有所减少，但差异无显著统计学意义（χ2=3.135，p=0.077）。结论：在化疗过程中，加用丙氨酰谷氨酰胺能一定程度上保护肠道，但并不能有效预防化疗致腹泻的发生。“,”Objective To investigate the role which alanyl-glutamine played in prevention and therapy of diarrhea induced by adjuvant chemotherapy of gastrointestinal cancer. Method Total 40 cases with gastrointestinal cancer treated by postoperative adjuvant chemotherapy were randomly divided into two groups.Control group,20 cases received chemotherapy alone,while observation group alanyl-glutamine+chemotherapy 20 cases. The incidence of diarrhea was observed.Results Incidence 0f diarrhea was l5%in observation group and 40%in control group.Compared with control group,the incidence of diarrhea with observation group has decreased,but the difference was not statistically significant(χ2=3.135,p=0.077). Conclusion In the course of chemotherapy,the addition of alanyl-glutamine,to some extent ,protect the intestinal tract,but it dose not prevent the occurence of chemotherapy-induced diarrhea effectively.