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目的:探讨温肾活血汤联合克罗米芬(clomiphene citrate,CC)促排卵治疗后对子宫内膜容受性的影响。方法:45例排卵障碍型不孕患者随机分成A组(CC)、B组(CC+阿司匹林)、C组(CC+温肾活血中药),每组15例。治疗1～3个疗程,观察排卵率、妊娠率及hCG注射日子宫内膜类型及厚度。结果:C组A+B型内膜率(91.18%)显著高于A组(76.92%,P<0.01)及B组(66.67%,P<0.05);C组内膜平均厚度(9.4±2.2mm)显著高于A组(7.8±1.4mm),P<0.05。周期排卵率C组(82.35%)>B组(76.92%)>A组(69.23%),但各组间无统计学差异(P>0.05);未破裂卵泡黄素化综合征(LUFS)发生率C组(5.88%)显著低于A组(23.08%)(P<0.05)。周期妊娠率C组(23.5%)>B组(15.4%)>A组(10.3%)(P<0.05)。结论:温肾活血汤能提高克罗米芬促排卵治疗后的妊娠率,其机制可能与促进排卵、降低LUFS发生及改善子宫内膜容受性有关,其改善内膜容受性的效果好于阿司匹林联合CC。
Objective: To investigate the effect of Wenshen Huoxue Decoction combined with clomiphene citrate (CC) on endometrial receptivity after ovulation induction. Methods: Forty-five patients with ovulation disorder infertility were randomly divided into A group (CC), B group (CC + aspirin) and C group (CC + Wenshen Huoxue Chinese medicine), 15 cases in each group. Treatment of 1 to 3 courses to observe the ovulation rate, pregnancy rate and hCG injection endometrial type and thickness. Results: The intimal percentage of group A + B in group C was significantly higher than that in group A (76.92%, P <0.01) and group B (66.67%, P <0.05) mm) was significantly higher than that in group A (7.8 ± 1.4mm), P <0.05. The rate of ovulation in group C was significantly higher than that in group C (82.35%)> group B (76.92%)> group A (69.23%), but there was no significant difference between groups (P> 0.05) Group (5.88%) was significantly lower than Group A (23.08%) (P <0.05). Cycle pregnancy rate in group C (23.5%)> group B (15.4%)> group A (10.3%) (P <0.05). Conclusion: Wenshenhuoxue Decoction can increase the pregnancy rate after clomiphene is administered by ovulation induction. The mechanism may be related to the promotion of ovulation, the reduction of LUFS and the improvement of endometrial receptivity. The improvement of endometrial receptivity is better than that of aspirin Joint CC.