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登革出血热(DHF)为登革病毒(DV)感染后出现的严重临床症状,其特征为血浆渗出和血液循环衰竭。由于观察到临床表现较重的患者血浆中有IL-8水平升高,作者研究了DV体外感染对炎症性细胞因子分泌表达的影响。对照组加入不含登革病毒2型(DV2)的昆虫细胞C6/36培养上清液后,ELISA测定其基线细胞因子水平,可见未感染DV2的容许性细胞293T(人上
Dengue haemorrhagic fever (DHF) is a severe clinical symptom that occurs after dengue virus (DV) infection and is characterized by plasma exudation and failure of blood circulation. Since elevated plasma levels of IL-8 were observed in patients with severe clinical manifestations, we investigated the effects of DV in vitro on the secretion of inflammatory cytokines. After adding C6 / 36 culture supernatant of insect cells without dengue virus type 2 (DV2) to the control group, baseline cytokine levels were measured by ELISA. As a result, it was found that the allowable cells 293T not infected with DV2