子痫前期病因各国研究学者产生多种学说:如过度炎症反应、内皮细胞功能障碍、氧化应激、RAAS(肾素血管紧张素系统)系统的作用等。本文讨论雌、雄激素在病理妊娠—子痫前期中的所产生的影响:雌激素能够抑制炎症反应、减少氧化因子对一氧化氮(NO)合成酶的破坏,促进NO合成、抑制RAAS系统活性,减少血管紧张素间的转化,起到舒血管的作用。而雄激素被认为与雌激素具有相互拮抗的作用。 Etiology of preeclampsia scholars from various countries produce a variety of theories: such as excessive inflammation, endothelial dysfunction, oxidative stress, RAAS (renin angiotensin system) system and so on. This article discusses the effects of estrogen and androgens in pathological gestational-preeclampsia: estrogen inhibits the inflammatory response, decreases the destruction of nitric oxide synthase by oxidants, promotes NO synthesis, and inhibits RAAS system activity , Reduce the conversion between angiotensin, play the role of vasodilator. Androgens are considered antagonistic to estrogen.