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目的:研究防哮饮联合吸入布地奈德对肺气虚证缓解期儿童哮喘的临床疗效,并探讨其对儿童肺功能和气道反应性的影响。方法:选取2015年6月~2016年6月在浙江省新华医院儿科就诊的112例肺气虚证缓解期哮喘患儿随机分为观察组和对照组,对照组患儿给予雾化吸入布地奈德治疗,观察组患儿雾化吸入布地奈德并口服防哮饮,疗程为3个月,比较治疗前后两组患儿的中医证候积分,并进行综合临床疗效评价,检测两组患儿的肺功能及呼吸道反应性。结果:(1)治疗后观察组患儿鼻痒喷嚏、流涕、咳嗽、气短、出汗、面色、语音、乏力、畏风等中医证候积分较对照组患儿显著降低(P<0.01);(2)观察组患儿总有效率显著高于对照组(P<0.05);(3)治疗后观察组患儿肺功能指标VT/kg、Ti/Te、TPTEF/TE、VPEF/VE、TEF25%、TEF50%及TEF75%均较对照组显著升高(P<0.01),Rr和PEF较对照组显著降低(P<0.01);(4)治疗后观察组患儿呼吸道反应性参数D_(min)、C_(min)、SGrs和SGrs/Grs均较对照组显著升高(P<0.01)。结论:防哮饮联合吸入布地奈德治疗肺气虚证缓解期哮喘患儿具有较好的临床疗效,可显著改善患儿的肺功能并降低其呼吸道反应性。
Objective: To study the clinical curative effect of anti-asthma drink inhalation of budesonide on asthma in children with remission of lung-qi deficiency syndrome and to explore its effect on children’s lung function and airway reactivity. Methods: From June 2015 to June 2016, 112 children with asthma with pulmonary qi deficiency syndrome who were treated in pediatric department of Xinhua Hospital of Zhejiang Province were randomly divided into observation group and control group. The control group was given budesonide Treatment, observation group children inhalation of budesonide and oral anti-asthma drink, the course of treatment was 3 months, comparing the two groups of children before and after treatment of TCM syndrome scores, and comprehensive clinical efficacy evaluation, detection of two groups of children Lung function and respiratory reactivity. Results: (1) The scores of syndromes of TCM such as nasal itching, runny nose, cough, shortness of breath, sweating, complexion, voice, weakness and wind sickness in the observation group were significantly lower than those in the control group (P <0.01) ; (2) The total effective rate in the observation group was significantly higher than that in the control group (P <0.05); (3) The pulmonary function indexes VT / kg, Ti / Te, TPTEF / TE, VPEF / TEF25%, TEF50% and TEF75% were significantly higher than those in the control group (P <0.01), and Rr and PEF were significantly lower than those in the control group (P <0.01); (4) After treatment, the respiratory reaction parameters D_ min, C min, SGrs and SGrs / Grs were significantly higher than those in control group (P <0.01). Conclusion: Combining anti-asthma decoction with inhaled budesonide in treating asthmatic children with remission of pulmonary qi deficiency syndrome has better clinical curative effect, can significantly improve children’s lung function and reduce their respiratory reactivity.