乙双吗啉(AT—1727)为一双内酰亚胺化合物,属ICRF—154的衍生物。实验证明为一有效的抗肿瘤药物。鉴于乙双吗啉在临床上用药时间长,特进行了本实验。实验表明:给大白鼠连续口服AT—1727 9个月,总量达2,925mg/kg及5,850mg/kg,对动物体重、血象及肝、肾功能无明显影响。组织学检查(包括心、肝、肺、脾、肾、肠和胃)未发现病理性改变。 Ethylbismorpholine (AT-1727) is a bisimide compound and is a derivative of ICRF-154. The experiment proved to be an effective anti-tumor drug. In view of the long-term clinical application of bis-morpholine, this experiment was performed. Experiments showed that: continuous administration of AT-1727 to rats for 9 months, the total amount of 2,925mg/kg and 5,850mg/kg, no significant effect on animal body weight, blood and liver and kidney function. Histological examinations (including heart, liver, lung, spleen, kidney, intestine and stomach) showed no pathological changes.