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目的：为探讨变异型跨膜糖蛋白ＣＤ４４（ＣＤ４４ｖ）在非小细胞肺癌中的表达及与淋巴结转移的关系。方法：用免疫组化的方法研究８４例手术切除非小细胞肺癌中ＣＤ４４ｖ的表达，统计分析其与淋巴结转移的关系。结果：５３２％的腺癌和５６７％的鳞癌有ＣＤ４４ｖ的表达；在有淋巴结转移的肺癌中ＣＤ４４ｖ表达的阳性率为９６９％，而无淋巴结转移的肺癌中其表达率仅为２８８％，两者差异具非常显著性。结论：ＣＤ４４ｖ的表达与非小细胞肺癌的淋巴结转移关系紧密，ＣＤ４４直接参与淋巴结的转移过程，是观察预后的一个重要指标，对于非小细胞肺癌的预后有重要意义。
Objective: To investigate the expression of variant transmembrane glycoprotein CD44 (CD44v) in non-small cell lung cancer and its relationship with lymph node metastasis. METHODS: Immunohistochemistry was used to study the expression of CD44v in 84 cases of surgically resected non-small cell lung cancer, and its relationship with lymph node metastasis was analyzed. RESULTS: The expression of CD44v was detected in 53. 2% of adenocarcinomas and 56.7% of squamous cell carcinomas. The positive rate of CD44v expression was 96.9% in lung cancers with lymph node metastasis. The expression rate of CD44v was found in lung cancer without lymph node metastasis. Only 28.8%, the difference between the two is very significant. Conclusion: The expression of CD44v is closely related to the lymph node metastasis of non-small cell lung cancer. CD44 is directly involved in the process of lymph node metastasis. It is an important index to observe the prognosis and is of great significance for the prognosis of non-small cell lung cancer.