论文部分内容阅读
目的 研究恶性视网膜母细胞瘤（ＲＢ）蛋白的表达与喉鳞癌的相关性。方法 采用免疫组化（ＡＢＣ）法检测４３例喉鳞癌患者手术标本中ＲＢ蛋白的表达。 结果 ＲＢ蛋白的表达阳性率为４４．２％；ＲＢ蛋白的表达与肿瘤的Ｔ分期、病理分级、５年生存期、肿瘤的原发部位无明显的相关性（Ｐ＞０．０５），但与淋巴结转移有关（Ｐ＜０．０５）。 结论 细胞调控周期中Ｃｙｃｌｉｎ Ｄ１、ＲＢ、Ｐ１６、ＣＤＫ４等因素在喉鳞癌的发生发展中可能起着协同作用，而并非主要由于ＲＢ基因的突变和缺失造成细胞癌变。
Objective To study the correlation between the expression of malignant retinoblastoma (RB) protein and laryngeal squamous cell carcinoma. Methods The expression of RB protein in 43 specimens of laryngeal squamous cell carcinoma was detected by immunohistochemistry (ABC) method. Results The positive expression rate of RB protein was 44.2%. There was no significant correlation between the expression of RB protein and T stage, pathological grade, 5-year survival time and tumor’s primary site (P> 0.05) And lymph node metastasis (P <0.05). Conclusions Cyclin D1, RB, P16, CDK4 and other factors may play synergistic roles in the development and progression of laryngeal squamous cell carcinoma but not mainly due to the mutation and deletion of RB gene.