论文部分内容阅读
目的:评价国产奥沙利铂(L-OHP,艾恒)联合氟尿嘧啶(5-FU)和亚叶酸钙(CF)方案治疗晚期胃肠癌的近期疗效和毒性反应。方法:27例晚期胃肠癌,其中胃癌9例,大肠癌18例,初治8例,复治19例,化疗前均经肘正中静脉留置中心静脉导管。给予FOLFOX方案,即L-OHP130mg/m2,静脉滴注4h,d1;CF 200mg/m2,静脉滴注2h,d1,5-FU 500mg于CF滴完后静脉推注,续以5-FU2.4~3.0g/m2持续静脉滴注48h,每3周重复。按WHO标准评价近期疗效和毒性反应。结果:全组患者获得PR12(51.9%)例,其中胃癌的有效率为44.4%;大肠癌的有效率为55.6%,初治有效率62.5%,复治有效率47.4%,统计学处理无明显差异(P>0.05)。主要毒副反应为恶心呕吐(74.0%)、口腔黏膜炎和腹泻(59.2%),以及一过性感觉异常(55.6%)。结论:国产奥沙利铂联合CF/5-FU组成的FOLFOX方案治疗晚期胃肠道癌有效率较高,不良反应轻,值得进一步推广。
OBJECTIVE: To evaluate the short-term efficacy and toxicity of domestic oxaliplatin (L-OHP) combined with 5-fluorouracil and leucovorin (CF) in the treatment of advanced gastrointestinal cancer. Methods: 27 cases of advanced gastrointestinal cancer, including 9 cases of gastric cancer, 18 cases of colorectal cancer, initial treatment in 8 cases, retreatment in 19 cases, before chemotherapy through the median vein indwelling central venous catheter. Given FOLFOX program, namely L-OHP130mg / m2, intravenous infusion of 4h, d1; CF 200mg / m2, intravenous infusion of 2h, d1,5-FU 500mg intravenous bolus after CF drops, followed by 5-FU2.4 ~ 3.0g / m2 continuous intravenous infusion 48h, repeated every 3 weeks. According to the WHO standard assessment of the recent efficacy and toxicity. Results: All the patients achieved PR12 (51.9%), the effective rate of gastric cancer was 44.4%, the effective rate of colorectal cancer was 55.6%, the effective rate of initial treatment was 62.5%, and the effective rate of retreatment was 47.4% Difference (P> 0.05). The main side effects were nausea and vomiting (74.0%), oral mucositis and diarrhea (59.2%), and transient anomalies (55.6%). CONCLUSION: FOLFOX regimen consisting of domestic oxaliplatin combined with CF / 5-FU is effective in treating advanced gastrointestinal cancers with mild adverse reactions and should be further popularized.