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目的观察甲氨蝶呤(methotrexate,MTX)联合米非司酮在药物保守治疗异位妊娠中的临床疗效。方法将2004年6月至2007年4月宜兴市中医医院妇产科药物保守治疗异位妊娠患者134例分为两组,对照组66例予MTX(50mg/m2)单次肌肉注射,研究组68例予MTX(50mg/m2)单次肌肉注射,同时每天口服米非司酮200mg连续3d,两组均定期监测血人绒毛膜促性腺激素(β-human chorionic gonadotrophin,β-HCG)水平,B超监测包块缩小情况。结果研究组治愈率(60例)88.2%,对照组治愈率(56例)84.8%,两组差异无统计学意义(P>0.05),研究组血β-HCG转阴时间、包块缩小率均优于对照组,差异显著有统计学意义(P<0.05)。结论MTX联合米非司酮治疗异位妊娠效果优于单独使用MTX。
Objective To observe the clinical efficacy of methotrexate (MTX) combined with mifepristone in the conservative treatment of ectopic pregnancy. Methods From June 2004 to April 2007, 134 cases of conservative treatment of ectopic pregnancy in obstetrics and gynecology department of Yixing Hospital of Traditional Chinese Medicine were divided into two groups. 66 cases in control group were given single intramuscular injection of MTX (50mg / m2) Sixty-eight patients were given intramuscular injection of MTX (50mg / m2) once a day for three consecutive days while mifepristone (200mg / d) was taken for three consecutive days. The levels of β-human chorionic gonadotrophin (β-HCG) B-monitoring mass shrinkage. Results The cure rate was 88.2% in the study group and 84.8% in the control group (P <0.05). There was no significant difference between the two groups (P> 0.05) All were better than the control group, the difference was statistically significant (P <0.05). Conclusion MTX combined with mifepristone treatment of ectopic pregnancy better than using MTX alone.