研究国产吗氯贝胺对抑郁动物模型和单胺氧化酶－Ａ（ＭＡＯ－Ａ）活性的影响。吗氯贝胺５、１０、２０ｍｇ·ｋｇ－１（ｉｇ）可显著对抗利血平（２．８ｍｇ·ｋｇ－１，ｓｃ）引起的大鼠眼睑下垂，其抑制率分别为６０％，８０％与９０％。在小鼠获得性“绝望”实验中，吗氯贝胺５，１５，２５ｍｇ·ｋｇ－１（ｉｇ）可明显缩短小鼠６ｍｉｎ内不动时间。本研究尚证实，吗氯贝胺６，１２，２４ｍｇ·ｋｇ－１（ｉｇ）可抑制小鼠脑组织中ＭＡＯ－Ａ活性，并与剂量呈明显依赖关系。一次给予小鼠２４ｍｇ·ｋｇ－１（ｉｇ），２ｈ后吗氯贝胺对ＭＡＯ－Ａ活性的抑制作用达高峰（７４．７％），４ｈ后ＭＡＯ－Ａ活性开始有所恢复，于用药后１６ｈ活性已基本趋于正常。 To study the effect of domestic moclobemide on the activity of monoamine oxidase-A (MAO-A) in animal models of depression. Moclobemide 5, 10 and 20 mg · kg-1 (ig) significantly inhibited the ptosis of rats induced by reserpine (2.8 mg · kg-1, sc) with the inhibition rates of 60% and 80% With 90%. In mice acquired “desperation” experiment, moclobemide 5,15,25 mg · kg-1 (ig) can significantly reduce the immobility time of mice within 6min. The study also confirmed that moclobemide 6,12,24mg · kg-1 (ig) can inhibit the MAO-A activity in mouse brain tissue and dose-dependent manner. After 24 hours, the inhibitory effect of moclobemide on MAO-A reached a peak (74.7%) at 24mg · kg-1 (ig) once. After 4h, MAO-A activity began to recover. 16h activity has basically normalized.