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目的:探讨左炔诺孕酮宫内缓释系统(LNG-IUS,曼月乐)对子宫动脉的血流动力学及子宫内膜厚度的影响。方法:对比放置LNG-IUS患者6个月前、后的子宫螺旋动脉搏动指数(PI)、阻力指数(RI)及子宫内膜厚度,并对其出现的不同月经模式进行比较。结果:1置LNG-IUS 6个月后子宫内膜变薄,子宫螺旋动脉PI值、RI值较置曼月乐前升高(P<0.05)。2置LNG-IUS后出现3种月经模式:月经规律组、闭经组及阴道不规则出血组。其中阴道不规则出血组PI值、RI值较置曼月乐前升高,且高于闭经组和月经规律组(P<0.05);闭经组、月经规律组与置LNG-IUS前比较PI值、RI值无明显变化(P>0.05),组间比较亦无统计学差异(P>0.05)。结论:置LNG-IUS后阴道不规则出血患者子宫螺旋动脉血流会发生改变。
Objective: To investigate the effect of levonorgestrel-releasing intrauterine system (LNG-IUS) on the hemodynamics and endometrial thickness of uterine artery. Methods: The uterine spiral beats pulsatility index (PI), resistance index (RI) and endometrial thickness were compared between LNG-IUS patients and their different menstruation patterns. Results: After 6 months of LNG-IUS, the endometrium became thinner and the PI value and RI value of uterine spiral artery were increased (P <0.05). There were 3 kinds of menstruation patterns after 2 sets of LNG-IUS: menstrual regular group, amenorrhea group and vaginal irregular bleeding group. The PI value and RI value in irregular vaginal bleeding group were significantly higher than those in pre-Mirena group and higher than those in menopausal group and menstrual regular group (P <0.05). Before amenorrhea group and menstrual regular group, the PI value , There was no significant change in RI (P> 0.05). There was no significant difference between groups (P> 0.05). Conclusion: Uterine spiral artery blood flow changes after LNG-IUS vaginal irregular bleeding.