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探讨小儿自体外周血造血干细胞移植预处理的近期和远期毒副作用 ,按Bearmen标准评价 2 1例接受治疗患儿的急性相关毒性反应 ,并对 11例术后生存 3年以上患儿随访。 14例无任何急性毒性反应 ;5例为Ⅰ级 ;2例为Ⅱ级。全部患儿身高及神经精神发育正常 ;2例有代偿性甲状腺功能低下 ;1例性腺发育延迟 ;6例轻度白内障 ;7例病毒性肝炎。提示患儿能耐受合适的预处理 ,远期影响小 ,生存质量高 ;在治疗中应注意预防病毒性肝炎
To investigate the short-term and long-term toxicities and side effects of pretreatment of pediatric autologous peripheral blood hematopoietic stem cell transplantation. According to Bearmen criteria, 21 patients with acute toxicity-related toxicity were evaluated and 11 children who survived for more than 3 years were followed up. 14 cases without any acute toxicity; 5 cases of grade Ⅰ; 2 cases of grade Ⅱ. All children with normal height and neuropsychiatric development; 2 patients with compensatory hypothyroidism; 1 case of delayed gonadal development; 6 cases of mild cataracts; 7 cases of viral hepatitis. Suggesting that children can tolerate the appropriate pretreatment, the long-term impact of small, high quality of life; in the treatment should pay attention to the prevention of viral hepatitis