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克林霉素为林可霉素的衍生物,抗菌谱与林可霉素相同,抗菌活性较林可霉素强4-8倍。因为克林霉素抗菌谱广,抗菌效力强,又无需做皮试,故临床应用广泛,ADR的发生也随之增多。根据最近文献报道,279例次(252例)克林霉素的ADR发生率为3．94％。为了探讨克林霉素所致ADR的特点,为临床合理用药提供参考,对近6年来国内应用克林霉素ADR的个案报道进行归纳分析如下:
Clindamycin, a derivative of lincomycin, has the same antibacterial spectrum as lincomycin, and its antibacterial activity is 4-8 times stronger than lincomycin. Because of clindamycin broad antibacterial spectrum, antibacterial and effective, but also do not need to do skin test, so a wide range of clinical applications, the occurrence of ADR will also increase. According to recent reports, 279 cases (252 cases) of clindamycin ADR incidence was 3.94%. In order to explore the characteristics of clindamycin-induced ADR, to provide a reference for clinical rational use of drugs, the domestic application of clindamycin ADR case reports of the past 6 years are summarized as follows: