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杂种犬１１只，股动脉放血使平均动脉压为６．０ｋＰａ，９０ｍｉｎ后回输全部血液。维拉帕米组于休克３０ｍｉｎ时输入维拉帕米１５０μｇ／ｋｇ。休克组于相同时间输入等量生理盐水。结果显示：与休克组相比较，维拉帕米治疗能降低小肠组织黄嘌呤氧化酶活性和脂质过氧化产物含量，增加锰超氧化物歧化酶活性，减轻小肠组织线粒体和肌质损伤程度。实验结果提示维拉帕米能保护休克小肠的结构和功能，其作用机理与抑制氧自由基生成有关。
11 hybrid dogs, femoral artery blood pressure so that the average arterial pressure of 6.0kPa, 90min after the return of all blood. The verapamil group received verapamil 150 μg / kg at 30 min of shock. The shock group received the same amount of saline at the same time. The results showed that compared with the shock group, verapamil could reduce xanthine oxidase activity and lipid peroxidation product content in the small intestine, increase manganese superoxide dismutase activity and mitigate mitochondrial and sarcoplasmic damage in the small intestine. The experimental results suggest that verapamil protects the structure and function of the shock small intestine, and its mechanism of action is related to inhibition of the production of oxygen free radicals.