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目的 :通过相关分析消除离体动脉不同节段反应差异对实验结果的影响。方法 :以生理多道记录仪记录离体大鼠胸主动脉环从下到上 4节段舒缩张力反应 ,用回归方程对舒缩反应节段性差异作等效转换。结果 :大鼠胸主动脉下段对苯肾上腺素收缩反应高于次下段、次上段和上段 ,次下段高于次上段、上段 (P <0 .0 5 ) ;下段对乙酰胆碱舒张反应高于次下段、次上段和上段 ,次下段高于次上段和上段 (P <0 .0 5 )。相关分析显示节段间收缩反应呈直线相关 ;舒张反应上段对下段呈曲线相关 ,余呈直线相关。按相关方程等效转换各动脉节段的舒缩反应 ,可消除反应的节段差异 (P >0 .0 5 )。结论 :通过回归方程作等效转换可消除动脉舒缩反应的节段性差异。
OBJECTIVE: To study the effect of different responses of isolated arteries to experimental results by correlation analysis. Methods: The systolic and diastolic responses of thoracic aorta rings from the inferior to the upper quadrant were recorded by physiological multi-channel recorder, and the segmental differences of systolic and diastolic responses were converted by regression equation. Results: The contraction of phenylephrine in the lower thoracic aorta of rats was higher than that of the second inferior segment, the inferior superior segment, the superior inferior segment, the inferior inferior segment above the inferior superior segment, the superior inferior segment (P <0.05), the lower acetylcholine relaxation response below the inferior inferior segment , The next upper and upper segments, and the second lower segment higher than the upper and lower segments (P <0.05). Correlation analysis showed that there was a linear correlation between the segmental response; the upper part of the diastolic response was curve-related to the lower part, and the rest was linearly related. According to the correlation equation, the systolic and diastolic responses of all arterial segments were equivalently converted, which could eliminate the segmental differences in response (P> 0.05). CONCLUSION: Segmental differences in arterial systolic and diastolic responses can be eliminated by using the regression equation as an equivalent conversion.