先证者男,2岁,因双下肢无力,走路不稳半年余于1990年12月27日入院。患儿系第1胎第1产,足月顺产,母乳喂养,8个月出牙,1岁3个月会走,但两下肢无力,走路不稳,并渐显两小腿曲呈“O”型,无抽搐,当地医院诊断为“佝偻病”。在5个月中先后共 The proband was male, 2 years old. She was hospitalized on December 27, 1990 due to the weakness of both lower extremities and unstable walking for more than half a year. Pediatric first-line fetus 1, term full-term, breastfeeding, 8 months teeth, 1 year old 3 months will go, but the two lower extremities weakness, walking instability, and gradually showed two calf music was “O ”Type, no convulsions, the local hospital diagnosed as “ rickets ”. In five months in succession