弥漫性肺骨化症(DPO)临床上十分罕见,常被误诊为肺部其他疾病。本病多继发于慢性肺部疾病,少数可为特发性。细胞组织损伤、炎症刺激、碱性环境、遗传易感性等多种因素共同参与其发病过程。影像学肺内发现弥漫分布粟粒状、分支状或珊瑚礁状钙化影应高度怀疑为本病,肺活检病理学检查肺内有成熟骨化灶是确诊本病的重要依据。 Diffuse pulmonary ossification (DPO) is clinically very rare and is often misdiagnosed as other lung diseases. The disease is more secondary to chronic lung disease, a few can be idiopathic. Cell damage, inflammatory stimuli, alkaline environment, genetic susceptibility and other factors to participate in the pathogenesis. Imaging findings found in the lung diffuse distribution of miliary, branching or coral reef-like calcification shadow should be highly suspected of the disease, lung biopsy pathological examination of mature lung ipsilateral lung is an important basis for the diagnosis of the disease.