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为探讨突发性聋的发病机制，测定和比较了２４例突发性聋病人治疗前后的血浆内皮素１（ＥＴ１）和降钙素基因相关肽（ＣＧＲＰ）含量的变化。发现：治疗有效组治疗前血浆ＥＴ１水平明显高于治疗后（Ｐ＜０．０５），而ＣＧＲＰ水平则明显低于治疗后（Ｐ＜０．０１）。提示：ＥＴ１升高和ＣＧＲＰ降低可能是突发性耳聋的发病因素之一。
To investigate the pathogenesis of sudden deafness, the changes of plasma endothelin-1 (ET-1) and calcitonin gene-related peptide (CGRP) in 24 patients with sudden deafness were measured and compared. Found: the effective treatment group before treatment plasma ET 1 levels were significantly higher than after treatment (P <0.05), while the CGRP levels were significantly lower than after treatment (P <0.01). Tip: ET 1 increased and CGRP decreased may be one of the pathogenesis of sudden deafness.